i-FILL
Accurate and Repeatable Large Volume Filling
i-FILL - Large Volume Filling
The i-FILL® is a hybrid piston/diaphragm pump that delivers repeatable dispense accuracy for larger fill volumes up to 100mL per piston stroke. This larger volume is ideal for quick product transfer.
The i-FILL Offers
- Semi-automated R&D, Lab, or Production Filling
- Fill volumes up to 100mL per stroke
- No tubing spallation
- Multiple dispensing and flow rate profiles that can be stored as recipes
- Ease of operation with its user-friendly interface
- Reduce CIP/SIP Protocols with a Single-Use Pump Head
Contact Us to Learn More About the i-FILL Micro
A user-friendly interface allows users to easily adjust fill volumes, fill speeds, and flow rates. These settings can be saved into recipes to fit specific unit operations.
Intellitech collaborated with University of South Florida to study the i-FILL pump and a leading peristaltic pump for cell viability.
2 studies have been conducted to examine the application of the i-FILL Micro pumps for transporting live cells. The team conducted Trypan-blue cell viability experiments with sample volume suspensions. In the first study, NIH-3t3 mouse fibroblast cells were used. In the second study, human donor T-cells were used. In both studies, the cells were examined via live-cell imaging. The 2nd study also utilized Presto-blue assays as another method for measuring cell viability.
In both studies, the results showed that the i-FILL Micro is capable for cell culture conditions during development and production. It is now qualified to be a viable alternative to the peristaltic pump.
While the i-FILL pump has performed purely as a highly accurate dispensing pump, it is not proven to be a highly capable cell transfer pump for both upstream and downstream cell culturing and bioprocessing, e.g. product transfer from a mixing vessel to filtration, from filtration to cell harvesting and transfer to either a finishing or a storage vessel.
Frequently Asked Questions on the i-FILL® Pump
What is the pump accuracy?
Pump accuracy depends on dispensing volume. For both the 1 mL and 10 mL kits, the largest volumetric accuracy is specified at ±2% for the lower end of the defined operating range. Within the mid-to-upper range of each kit, performance improves significantly, achieving ±0.25% accuracy across continuous runs of hundreds or thousands of dispenses.
For example, the 10 mL kit demonstrated ±2% accuracy at volumes as low as approximately 0.3 mL, while accuracy tightened to ±0.25% at mid and higher volumes (1ml to 19 mL). Testing was performed using water-like fluids, with no special temperature controls, and results reflect consistent, repeatable performance over hundreds of dispenses rather than single-point claims.
How easy is it to prime the pump?
Priming the pump is designed to be straightforward and quick. The user mounts the appropriate single-use kit and selects a predefined priming recipe based on kit size. After placing the intake tubing into the source container, the user initiates priming with the push of a button. Within three to four dispenses, the pump is primed such that air is expelled from the tubing set and the system is ready for operation. The process does not involve complex tubing paths or manual adjustments.
Is the pump compliant to 21 CFR 11?
The pump supports key elements required for 21 CFR Part 11 compliance, including user access controls. Users must log in to modify pump parameters, ensuring controlled access to configuration settings. Operators can run pre-configured recipes without altering parameters, while administrative changes require appropriate credentials. These features support regulated environments where electronic access control and traceability are required.
Can the pump be validated?
Yes. The pump can be validated, and it is currently used in validated environments by existing customers. Validation protocols are available and align with the performance testing demonstrated during the webinar. Validation typically involves identifying the pump, recording operating parameters, running samples, and measuring dispensing results over time to confirm repeatability and consistency.
Does the pump need to be calibrated?
The pump itself does not require routine calibration or annual factory recalibration. However, best practice is to perform a benchmarking step for each new single-use kit. After priming, users are encouraged to run the pump onto a balance and verify the dispense volume. If needed, piston stroke length can be adjusted to fine-tune the volume. Once this initial adjustment is made, the kit can be considered set for use. This process accounts for minor kit-to-kit variability and ensures target volumes are met.
Does the pump require specialty tubing?
No specialty tubing is required. Standard kits use platinum-cured silicone tubing, supported by material certifications. However, kits can be customized if a different material, length, or configuration is required for a specific application, examples include tubing weights, fill bells, etc. Customization options are available, allowing users to select tubing that meets their process or regulatory needs without requiring proprietary or uncommon materials.
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Intellitech Products
Many of our customers are involved in biologic drug/therapy/vaccine R&D and transitioning to GMP production and we, at Intellitech, believe we can best support those efforts by continuing to focus on manufacturing and improving the i-FILL family of precision liquid dispensing pump technology and single-use systems.